Mitochondrial tRNA mutations in patients with myelodysplastic syndromes.
نویسندگان
چکیده
Increasing evidence showed that mitochondria play an important role in the development of myelodysplastic syndromes (MDS). Mitochondrial dysfunctions caused by mitochondrial DNA mutations, especially mitochondrial tRNA mutations, were found to be associated with MDS in many studies. However, the link between a candidate mitochondrial tRNA mutation and MDS was not clear. In this study, we investigated the role of some mitochondrial tRNA mutations, and their deleterious roles were further discussed.
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ورودعنوان ژورنال:
- Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis
دوره 27 4 شماره
صفحات -
تاریخ انتشار 2003